Which Women’s Supplement Is Actually Worth It? I Compared 5 of the Most Popular Options – Here’s the Verdict

As a physician with over 25 years in internal medicine, I talk to women every day who just feel off.

Low energy. Mood swings. Bloating. Irregular cycles. Or that sense that your body isn’t cooperating anymore. And if you’ve already tried a bunch of supplements hoping something would finally click? You’re not alone.

The market is overflowing with options—but most don’t fix the issue I see most often in practice: women are depleted in foundational nutrients like iron, B vitamins, zinc, folate, and vitamin A.

So I looked at the five supplement types women ask me about most, and I compared them based on nutrient quality, absorption, hormone relevance, completeness, and ease of use.

Spoiler: one option stood out big time.

1. Primal Queen: The Most Complete Option for Women Who Feel Depleted

Let’s cut to the chase: Primal Queen is the supplement I recommend most often.

Not because it’s trendy. Not because it promises some magical “hormone hack,” but because it addresses the real problem I see constantly in practice: women are missing raw materials.

Primal Queen is made from six grass‑fed beef organs, including uterus, ovaries, and fallopian tubes, plus liver, heart, and kidney.That matters, because this blend naturally provides key nutrients women commonly struggle to get enough of, including:

• Heme iron Retinol (true vitamin A)
• B12
• Natural folate
• Zinc
• Selenium
• CoQ10

And in real life, the form matters as much as the dose:

• Heme iron absorbs better than plant‑based iron
• Retinol is more usable than beta‑carotene
• Natural folate behaves differently than folic acid

It’s also incredibly easy to take: two peppermint‑scented capsules daily, no taste, no mixing, no prep.

✅ Best for: Women who feel depleted and want true nutrient repletion
💡 Hot tip: If you’ve tried “hormone support” before and didn’t feel much, start with foundations first.

2. Liver Pills: Helpful for Iron and B12, But Not the Full Picture

Liver pills can absolutely be beneficial. They are rich in Iron, B12, and Vitamin A.

So if you’re specifically trying to support iron levels or basic energy, liver supplements can be a solid step up from many drugstore options. But liver‑only formulas are inherently limited. You are missing nutrients found in hearts (like CoQ10) and kidneys (like selenium).

And you’re also missing the female organ focus that many women prefer for cycle rhythm support. Liver pills can be a good “starter,” but they typically aren’t as complete as a multi‑organ formula.

✅ Best for: Women who want a simple organ supplement focused on iron
❌ Skip if: You want a more complete, full‑spectrum nutrient profile

3. Drugstore Multivitamins: Convenient, But Often Poorly Absorbed

This is one of the most common scenarios I see:

“I’ve been taking a multivitamin every day… and I still don’t feel better.”

That’s because most drugstore multivitamins use synthetic forms of nutrients – like Non-heme iron (less absorbable) and Folic Acid (not the same as natural folate).

And many women find these formulas harder on digestion. They can help fill in minor gaps, and they’re convenient, but for women who are truly depleted, multivitamins often don’t move the needle the way they hope.

✅ Best for: Women who want a basic, low‑effort supplement
❌ Skip if: You’ve been taking one for months and still feel “off”

4. Hormone Blends: Can Be Supportive, But Often Miss the Root Issue

Hormone blends are one of the most marketed categories right now. And yes, some of them can be helpful, but here’s what I wish more women understood: Hormones aren’t something you “add in.”

They’re built and regulated by the body using nutrients. So if the body doesn’t have enough foundational nutrients—iron, B vitamins, zinc, vitamin A—it’s much harder for it to regulate smoothly. This is why hormone blends can feel hit‑or‑miss.

If you already have a solid nutrient foundation, they may offer additional support. But if you’re depleted, you may not feel much at all. If you’re looking for a higher‑quality option in this category, Thorne Hormone Advantage is one of the better‑formulated blends I’ve seen.

✅ Best for: Women who already have strong nutrition and want targeted support
❌ Skip if: You’re low‑energy, depleted, or not absorbing well

5. Greens Powders: Great for Digestion… But Not a True Nutrient Repletion Tool

Greens powders are popular for a reason. They can be great for supporting digestion, adding more plant variety, and helping women feel “cleaner” or less bloated.

But, most green powders are not a reliable source of nutrients women are most commonly missing. They generally do not have meaningful amounts of heme iron, retinol vitamin A, B12, or bioavailable zinc.

And because greens powders are processed, potency can vary widely. They can be a nice add‑on, but they’re rarely the solution for women who feel depleted.

✅ Best for: Women who want a daily digestion + micronutrient boost
❌ Skip if: You’re trying to fix fatigue, low iron symptoms, or hormonal rhythm issues

Final Verdict: Primal Queen Is the Clear Winner

While every supplement category has its place, Primal Queen stood out as the most complete and effective option for the women I see most often: Women who are doing everything “right”… but still feel off.

Most women don’t need more supplements, they need better nourishment in forms the body can actually use.

That’s why, after years of reviewing products and tracking patient feedback, Primal Queen is the supplement I recommend most often for women who want steadier energy, more stable mood, and better cycle rhythm support.

If you’ve been feeling stuck, the missing piece may not be effort. It may be nutrient replenishment.